免费又黄又爽又色的视频,久久精品无码一区二区日韩av,2020国产91精品对白露脸,91福利视频一区二区

歡迎光臨上海懋康生物科技有限公司
主頁 > 產(chǎn)品中心 > 生化試劑 > Rapamycin 雷帕霉素 > mz0201Rapamycin雷帕霉素
產(chǎn)品中心
Rapamycin雷帕霉素

Rapamycin雷帕霉素

簡要描述:

Rapamycin雷帕霉素用途及描述:科研試劑,廣泛應(yīng)用于分子生物學(xué),藥理學(xué)等科研方面。雷帕霉素(西羅mo司)是目前世界上的強效免疫抑制劑。

產(chǎn)品時間:2024-03-21

打印當(dāng)前頁

分享到:

Rapamycin雷帕霉素參數(shù)



Rapamycin (Sirolimus) 雷帕霉素(西羅mo司)

別  名

西羅mo司(sirolimus)



Cas 號

53123-88-9

分子式

C51H79NO13

分子量

914.18

結(jié)構(gòu)式



Rapamycin雷帕霉素定義:

一種新型大環(huán)內(nèi)酯類免疫抑制藥物。通過與相應(yīng)免疫嗜素RMBP結(jié)合抑制細(xì)胞周期G0期和G1期,阻斷G1進(jìn)入S期而發(fā)揮作用,其效應(yīng)為:①抑制T和B細(xì)胞增殖;②抑制IL-1、IL-2、IL-6和IFN-γ誘導(dǎo)的淋巴細(xì)胞增殖;③抑制IgG和供者特異性抗體(細(xì)胞毒抗體)產(chǎn)生;④抑制單核細(xì)胞增殖。可用于抗移植排斥反應(yīng)和治療類風(fēng)濕性關(guān)節(jié)炎、紅斑狼瘡等自身免疫病。

溶解性:可溶解于DMSO (50mg/ml)、甲醇(50 mg/ml)、乙醇、丙酮、等有機溶劑;幾乎不溶于水。

作用

本品抑制由抗原和細(xì)胞因子(白介素IL-2、IL-4和IL-15)激發(fā)的T淋巴細(xì)胞的活化和增殖,它亦抑制抗體的產(chǎn)生。在細(xì)胞中,西羅mo司與免疫嗜素,即FK結(jié)合蛋白-12(FKBP-12)結(jié)合,生成FKBP-12免疫抑制復(fù)合物。此復(fù)合物與哺乳動物的西羅mo司BA分子(mTOR,一種關(guān)鍵的調(diào)節(jié)激酶)結(jié)合并抑制其活性,從而抑制細(xì)胞周期中G1期向S期的發(fā)展。

Trusted Worldwide: more than 10,000 vials of our rapamycin have been shipped to more than 2,500 laboratories worldwide since 2002.

Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed to FK-506 binding protein. Selectively blocks signaling that leads to p70 S6 kinase activation (IC50 = 50 pM). Terada, N., et al. "Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase." J. Biol. Chem. 268: 12062-12068 (1993). Fingar, D.C., et al. "Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes." J. Biol. Chem. 268: 3005-3008 (1993). Price, D.J., et al. "Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase." Science 257: 973-977 (1992). Chung, J., et al. "Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases." Cell 69: 1227-1236 (1992).

Lymphokine-induced cell proliferation at the G1 phase is inhibited and apoptosis in a murine B cell line is induced by rapamycin. Rapamycin arrests the Saccharomyces cerevisiae cell cycle irreversibly in the G1 phase. Morice, W.G. ,et al. "Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes." J. Biol. Chem. 268: 3734-3738 (1993). Kay, J.E., et al. "Inhibition of T and B lymphocyte proliferation by rapamycin." Immunology 72: 544-549 (1991). Heitman, J., et al. "Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast." Science 253: 905-909 (1991).

Rapamycin extended median and maximal lifespan of both male and female mice when fed late in life. Harrison, D.E., et al. "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice." Nature 460: 392-395 (2009).

Rapamycin has shown activity in slowing cellular and organismal aging. Rapamycin abolished nuclear blebbing, delayed the start of cellular senescence, and improved the degradation of progerin in Hutchinson-Gilford progeria syndrome fibroblast cells. It also reduced the formation of insoluble progerin aggregates and resulted in clearance through autophagic mechanisms in normal fibroblasts. Cao, K., et al. "Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells." Sci. Transl. Med. 3: 89ra58 (2011).

Due to a different mechanism of action than FK506 and other immunosuppressants, rapamycin may prove to be important in organ transplant patient therapy. Fewer side effects than the standard anti-rejection treatments have been observed. Proliferation of activated T cells, but not apoptosis, is blocked by rapamycin. The induction of apoptosis of rejection-causing T cells reduces the tendency towards transplant rejection. Schwarz, C. and Oberbauer, R. "The future role of target of rapamycin inhibitors in renal transplantation." Curr Opin Urol. 12: 109-113 (2002). Wells, A.D. et al. "Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance." Nat. Med. 5: 1303-1307 (1999). Li, Y., et al. "Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance." Nat. Med. 5: 1298-1302 (1999).

We have had one lot of Selleck Chemical's rapamycin analyzed by a highly experienced and expert clinical analytical laboratory that specializes in rapamycin analyses. Using liquid chromatography - mass spectrometry, they found a purity of 96.7% (cis plus trans) for a lot of Selleck's rapamycin. In contrast, we have proven our rapamycin to be greater than 99% in purity for every lot, no exceptions.

More on the subject of rapamycin purity: HPLC analysis of rapamycin is somewhat complicated. Rapamycin forms several chromatographically separable species in solution, consisting perhaps of different conformers, tautomers, hydrates and/or isomers, but they are all in equilibrium with the major form, trans-rapamycin. We have shown this by collecting the individual impurity peaks in our rapamycin product and individually re-injecting them into the HPLC. In each case, upon re-injection the collected impurity peak is reduced or absent, and the major peak is again trans-rapamycin, of ~95% purity or higher, thus confirming re-equilibration back to the major trans-isomer of rapamycin. Because we find that all significant impurities (generally, those above 0.1%) in our product, including the cis-isomer, are in equilibrium with the trans isomer in the solution used for analysis, the actual purity of our product is >99% rapamycin, in all of its equilibrium forms. In contrast, material from other suppliers typically contains impurities that do not equilibrate with trans-rapamycin, and thus are genuine contaminants. These results also indicate that it is probably not possible to obtain the trans isomer in pure form, because in solution it will quickly re-equilibrate to the mixture of cis and trans.

儲存條件:-20℃,避光防潮密閉干燥。


訂購信息:

品名

產(chǎn)地

貨號

規(guī)格

單價

備注

Rapamycin (Sirolimus) 雷帕霉素(西羅mo司)

MKbio

MZ0201-10MG

10MG

248

現(xiàn)貨

Rapamycin (Sirolimus) 雷帕霉素(西羅mo司)

MKbio

MZ0201-100MG

100MG

680

現(xiàn)貨

上海懋康生物科技有限公司是一家涉足于生命科學(xué)和生物技術(shù)領(lǐng)域研究的試劑、儀器和實驗室消耗品與實驗服務(wù)工作,主要從事細(xì)胞生物學(xué)、植物學(xué)、分子生物學(xué)、免疫學(xué)、生物化學(xué)、蛋白組學(xué)。生物制藥與診斷試劑研發(fā)生產(chǎn)等領(lǐng)域。 本公司秉承“以人為本,以誠為信、合同守信"的經(jīng)營理念。堅持"品質(zhì)保障"的原則為廣大客戶提供優(yōu)質(zhì)產(chǎn)品。
懋康生物精選*品牌和國內(nèi)經(jīng)過認(rèn)證的、質(zhì)量較為可靠、有質(zhì)量體系管理的產(chǎn)品供應(yīng)商的產(chǎn)品,能夠根據(jù)課題需要,提供基于免疫學(xué)、分子生物學(xué)和細(xì)胞生物學(xué),微生物學(xué)產(chǎn)品組合。通過進(jìn)口產(chǎn)品和國內(nèi)精選、質(zhì)量可靠的產(chǎn)品組合,保證您的課題能順利、甚至高質(zhì)量完成。
如果懋康生物沒有您需要采購的產(chǎn)品,我們也會向您推薦優(yōu)質(zhì)供應(yīng)商,讓您自行選擇和參考。懋康生物作為yiuxiu的專業(yè)科研整體試劑服務(wù)提供商。匯聚了具有嚴(yán)格質(zhì)控體系的試劑供應(yīng)商及經(jīng)驗豐富的生物專業(yè)學(xué)術(shù)人員,致力于為中國醫(yī)學(xué)與生物科研提供*的生物試劑咨詢導(dǎo)購,節(jié)省您的實驗時間和經(jīng)費,為您的論文發(fā)表保駕護(hù)航!

特級胎牛血清(北美血源)

GIBCO

16000-044

500ml

特級胎牛血清(澳洲血源)

GIBCO

10099-141

500ml

普通型胎牛血清(南美血源)

Hyclone

SV30087.02

500ml

特級胎牛血清(澳洲血源)

Hyclone

SH30084.03

500ml

標(biāo)準(zhǔn)型胎牛血清(澳大利亞來源)

Hyclone

SH30370.03

500ml

特級胎牛血清(北美血源)

Hyclone

SH30070.03

500ml

胎牛血清  烏拉圭

GIBCO

C2027050

500ml

MSC QUALIFIED FBS

GIBCO

12662029

500ml

FBS, HI

GIBCO

10438026

500ml

FBS, ES CELL QUAL. USDA APPD.

GIBCO

10439024

500ml

FBS, DIALYZED, USA ORIGIN

GIBCO

26400044

500ml

FBS QUALIFIED, USA ORIGIN

GIBCO

26140079

500ml

FBS, ES CELL QUAL, USA ORIGIN

GIBCO

16141079

500ml

FBS, HI

GIBCO

16140071

500ml

巴西胎牛

GIBCO

12657029

500ml

新生牛血清

GIBCO

16010159

500ml

FOETAL BOVINE SERUM

Hyclone

SH30406.02

500ml

New Zealand Calf Serum

Hyclone

SH30401.01

500ml

FetalClone®II

Hyclone

SH30066.02

100ml

STANDARD FETAL BOVINE SERUM

Hyclone

SH30088.03

500ml

Newborn Bovine Calf Serum, U.S. Origin

Hyclone

SH30118.02

100ml

FETAL BOVINE SERUM

Hyclone

SH30070.02

100ml

COSMIC CALF®SERUM

Hyclone

SH30087.02

100ml

FETALBOVINESERUM CHARACTERIZSED

Hyclone

SH30070.03E

500ml

FetalClone®I

Hyclone

SH30080.03

500ml

FETAL BOVINE SERUM CHARACTERIZED

Hyclone

SH30396.03

500ml

FETAL BOVINE SERUM

Hyclone

SH30071.03

500ml

FETAL BOVINE SERUM

Hyclone

SH30071.02

100ml

FetalClone®I

Hyclone

SH30080.02

100ml

FETAL BOVINE SERUM CHARACTERIZSED

Hyclone

SH30070.02E

100ml

FETAL BOVINE SERUM

Hyclone

SH30079.02

100ml

CHARCOAL/DEXTRAN TREATED FBS

Hyclone

SH30068.02

100ml

CHARCOAL/DEXTRAN TREATED FBS

Hyclone

SH30068.03

500ml

FetalClone®II

Hyclone

SH30066.03

500ml

HyClone FetalClone®III

Hyclone

SH30109.03

500ml

STANDARD FETAL BOVINE SERUM

Hyclone

SH30088.03

500ml

STANDARD FETAL BOVINE SERUM

Hyclone

SH30088.02

100ml

FETAL BOVINE SERUM

Hyclone

SH30079.03

500ml

馬血清

Hyclone

SH30074.03

500ml

1640培養(yǎng)基 1640 Medium

GIBCO

31800-022

10X1L

DMEM(高糖)含丙酮酸鈉

GIBCO

12800-017

10X1L

DMEM(高糖) DMEM(High Glucose)

GIBCO

12100-046

10X1L

DMEM(低糖)DMEM(Low Glucose)

GIBCO

31600-034

10X1L

MEM 培養(yǎng)基

GIBCO

41500-034

10X1L

M199培養(yǎng)基 M199 Medium

GIBCO

31100-035

10X1L

F12培養(yǎng)基

GIBCO

21700-075

10X1L

DMEM/F12培養(yǎng)基

GIBCO

12400-024

10X1L

IMDM培養(yǎng)基

GIBCO

12200-036

10X1L

DMEM(高糖)培養(yǎng)液

Hyclone

SH30022.01B

500ml

DMEM(低糖) 培養(yǎng)液

Hyclone

SH30021.01B

500ml

1640培養(yǎng)液

Hyclone

SH30809.01B

500ml

DMEM/F12培養(yǎng)液

Hyclone

SH30023.01B

500ml

α-MEM培養(yǎng)液

Hyclone

SH30265.01B

500ml

MEM/EBSS培養(yǎng)液

Hyclone

SH30265.01B

500ml

胰蛋白mei/EDTA消化液

Hyclone

SV30042.01

100ml

青/鏈mei素濃縮液

Hyclone

SV30010

100ml

Lipofectamine® 2000 Transfection Reagent
            脂質(zhì)體2000

GIBCO

11668-027

0.75ml

Lipofectamine® 2000 Transfection Reagent
            脂質(zhì)體2000

GIBCO

11668-019

1.5ml

B-27® Serum-Free Supplement (50X), Liquid
           

GIBCO

17504-044

10ml

N-2 Supplement (100X), Liquid
           

GIBCO

17502-048

5ml

G-5 Supplement (100X), Liquid

GIBCO

17503-012

1ml

SUPERSCRIPT II

invitrogen

18064014

 

SUPERSCRIPT III

invitrogen

18080044

 

SUPERSCRIPT III 1ST

invitrogen

18080051

 

Wizard® SV Gel and PCR Clean-Up System

promega

A9281

50 preps

Wizard® SV Gel and PCR Clean-Up System

promega

A9282

250 preps

Wizard® SV Gel and PCR Clean-Up System

promega

A9285

1000 preps

Dual-Glo™ Luciferase Assay System

promega

E2920

10ml

Dual-Glo™ Luciferase Assay System

promega

E2940

100ml

Dual-Glo™ Luciferase Assay System

promega

E2980

10 × 100ml

Dual-Luciferase® Reporter Assay System

promega

E1910

100 assays

Dual-Luciferase® Reporter Assay System 10-Pack

promega

E1960

1,000 assays

Dual-Luciferase® Reporter 1000 Assay System

promega

E1980

1,000 assays

ImProm-II™ Reverse Transcriptase

promega

A3803

500 reactions

ImProm-II™ Reverse Transcription System

promega

A3800

100 reactions

Reverse Transcription System

promega

A3500

100 reactions

CellTiter 96® Non-Radioactive Cell Proliferation Assay

promega

G4000

1,000 assays

CellTiter 96® Non-Radioactive Cell Proliferation Assay

promega

G4100

5,000 assays

CellTiter 96® AQueous One Solution Cell Proliferation Assay

promega

G3580

1,000 assays

CellTiter 96® AQueous One Solution Cell Proliferation Assay

promega

G3581

5,000 assays

CellTiter 96® AQueous One Solution Cell Proliferation Assay

promega

G3582

200 assays

CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay

promega

G5421

1,000 assays

CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay

promega

G5430

5,000 assays

CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay

promega

G5440

50,000 assays

pGEM®-T Easy Vector System I

promega

A1360

20 reactions

pGEM®-T Easy Vector System II

promega

A1380

20 reactions

DeadEnd™ Fluorometric TUNEL System

promega

G3250

60 reactions

DeadEnd™ Colorimetric TUNEL System

promega

G7130

40 reactions

DeadEnd™ Colorimetric TUNEL System

promega

G7360

20 reactions

M-MLV Reverse Transcriptase

promega

M1701

10,000u

M-MLV Reverse Transcriptase

promega

M1705

50,000u

GoTaq® qPCR Master Mix,

promega

A6001

200 Reactions

GoTaq® qPCR Master Mix,

promega

A6002

1000 Reactions

Wizard® DNA Clean-Up System

promega

A7280

100 preps

SV Total RNA Isolation System

promega

Z3100

50 preps

SV Total RNA Isolation System

promega

Z3101

10 preps

SV Total RNA Isolation System

promega

Z3105

250 preps

CellTiter-Glo® Luminescent Cell Viability Assay

promega

G7570

10ml

CellTiter-Glo® Luminescent Cell Viability Assay

promega

G7571

10 × 10ml

CellTiter-Glo® Luminescent Cell Viability Assay

promega

G7572

100ml

CellTiter-Glo® Luminescent Cell Viability Assay

promega

G7573

10 × 100ml

PepTag® Non-Radioactive PKC Assay

promega

V5330

120 reactions

PepTag® Non-Radioactive cAMP-Dependent Protein Kinase Assay

promega

V5340

120 reactions


留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補充說明:

  • 驗證碼:

    請輸入計算結(jié)果(填寫阿拉伯?dāng)?shù)字),如:三加四=7
  • © 2019 上海懋康生物科技有限公司 版權(quán)所有 技術(shù)支持:環(huán)保在線
  • 電 話:18616957973 傳 真:86-021-54736159 QQ號碼:1563822900 郵 箱:2971634497@qq.com 地 址:上海市閔行區(qū)虹梅南路2588號綠亮科創(chuàng)園1幢A棟321室
  • 備案號:滬ICP備16016464號-3 總訪問量:521157
在線客服 聯(lián)系方式

服務(wù)熱線

18616957973

民乐县| 砀山县| 达孜县| 梅河口市| 水城县| 中宁县| 腾冲县| 龙川县| 安吉县| 仪征市| 绍兴县| 中山市| 沂水县| 宜兰市| 新沂市| 竹山县| 平果县| 会宁县| 潞城市| 城口县| 洱源县| 漳平市| 奉化市| 陆川县| 依兰县| 左权县| 临朐县| 望都县| 达州市| 江源县| 高唐县| 新田县| 万盛区| 舞阳县| 库车县| 横峰县| 辽宁省| 财经| 胶州市| 同心县| 深水埗区|